MolNFT v1 · #58535 · protein
Crystal structure of the GLUR2 ligand binding core (S1S2J) mutant T686A in complex with glutamate at 2.0 resolution
3B6Q · Glutamate receptor 2: “Crystal structure of the GLUR2 ligand binding core (S1S2J) mutant T686A in complex with glutamate at 2.0…”. X-ray diffraction, 2 ligands (GLU, SO4), 2 pockets (best druggability 0.42). MolNFT v1 #58535 on…
- PDB
- 3B6Q
- Type
- protein
- Length
- 258 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P19491
- Ligands
- GLU, SO4
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 2 | protein | 258 | 39% helix, 21% strand | P19491 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.42 | 0.76 | 26 | SO4 |
| 2 | 50 | 0.34 | 0.78 | 13 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3B6Q · Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) Mutant T686A in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 3B6Q · PDBe 3B6Q · UniProt P19491
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