MolNFT v1 · #58490 · protein

Crystal structure of the unstable and highly fibrillogenic PRO7SER mutant of the recombinant variable domain 6AJL2

3B5G · Amyloid lambda 6 light chain variable region pip: “Crystal structure of the unstable and highly fibrillogenic PRO7SER mutant of the recombinant variable domain…”. X-ray diffraction, 1 ligand (NA), 1 pocket (best druggability 0.48).…

PDB: 3B5G
Type: protein
Length: 222 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Amyloid lambda 6 light chain variable region pip
Ligands: NA
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Amyloid lambda 6 light chain variable region pip	protein	111	8% helix, 47% strand	—

Ligands and binding sites

NA · Sodium ion · metal · chains A
GOL · Glycerol · additive · 7 copies · chains A, B
ACT · Acetate ion · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.48	0.76	37	ACT

Interfaces

1 interface between chains.

A–B · 586 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3B5G · Crystal Structure of the Unstable and Highly Fibrillogenic PRO7SER Mutant of the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3B5G · PDBe 3B5G

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