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Crystal structure of the unstable and highly fibrillogenic PRO7SER mutant of the recombinant variable domain 6AJL2

Analyse Crystal structure of the unstable and highly fibrillogenic PRO7SER mutant of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3B5G
Type: protein
Length: 222 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Amyloid lambda 6 light chain variable region pip
Ligands: NA
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Amyloid lambda 6 light chain variable region pip	protein	111	8% helix, 47% strand	—

Ligands and binding sites

NA · Sodium ion · metal · chains A
GOL · Glycerol · additive · 7 copies · chains A, B
ACT · Acetate ion · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.48	0.76	37	ACT

Interfaces

1 interface between chains.

A–B · 586 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3B5G · Crystal Structure of the Unstable and Highly Fibrillogenic PRO7SER Mutant of the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3B5G · PDBe 3B5G

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