MolNFT v1 · #58344 · protein

Crystal structure of alpha-lactalbumin

3B0K: “Crystal structure of alpha-lactalbumin”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.62). MolNFT v1 #58344 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3B0K
Type: protein
Length: 240 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-lactalbumin
UniProt: P00712
Ligands: CA
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Alpha-lactalbumin	protein	120	46% helix, 10% strand	P00712

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	418	0.62	0.77	41	empty
2	76	0.35	0.75	14	empty
3	51	0.33	0.78	14	empty

Interfaces

1 interface between chains.

A–B · 769 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

3B0K · Crystal structure of alpha-lactalbumin · the same entry in another collection · chain A against A, TM-score 1.00
P00712 · AlphaFold monomer V2.0 prediction for alpha-lactalbumin (P00712) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00712
Elsewhere: RCSB PDB 3B0K · PDBe 3B0K · UniProt P00712

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.