MolNFT v1 · #58195 · protein + RNA
Structure of viral RNA polymerase complex 2
3AVU · Elongation factor ts, elongation factor tu, linker, Q beta…: “Structure of viral RNA polymerase complex 2”. X-ray diffraction, 1 ligand (CA), 15 pockets (best druggability 0.83). MolNFT v1 #58195 on GenesisL1: 3D structure, binding…
- PDB
- 3AVU
- Type
- protein + RNA
- Length
- 1,219 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor ts, elongation factor tu, linker, Q beta replicase; RNA…
- UniProt
- P0A6P3, P0A6N3, Q8LTE0
- Ligands
- CA
- Pockets
- 15 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor ts, elongation factor tu, linker, Q beta replicase | protein | 1203 | 36% helix, 21% strand | P0A6P3, P0A6N3, Q8LTE0 |
| G | RNA (5'-R(*GP*GP*GP*UP*CP*CP*A)-3') | rna | 7 | — | — |
| T | RNA (5'-R(*AP*UP*CP*GP*UP*GP*GP*AP*CP*CP*CP*A)-3') | rna | 9 | — | — |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 943 | 0.83 | 0.84 | 98 | CA |
| 2 | 639 | 0.69 | 0.78 | 73 | empty |
| 3 | 319 | 0.63 | 0.80 | 50 | empty |
| 4 | 135 | 0.53 | 0.81 | 26 | empty |
| 5 | 108 | 0.50 | 0.81 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–T · 977 Ų buried · 18 hydrogen bonds · protein-nucleic
- A–G · 740 Ų buried · 20 hydrogen bonds · protein-nucleic
- G–T · 367 Ų buried · 30 hydrogen bonds · nucleic-nucleic
Compared structures
- 3AVU · Structure of viral RNA polymerase complex 2 · the same entry in another collection · chain A against A, TM-score 1.00
- P0A6P3 · AlphaFold monomer V2.0 prediction for elongation factor ts (P0A6P3) · a predicted model of the same protein · chain A against A, TM-score 0.20
- P0A6N3 · AlphaFold monomer V2.0 prediction for elongation factor tu (P0A6N3) · a predicted model of the same protein · chain A against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6P3
- Every structure of UniProt P0A6N3
- Every structure of UniProt Q8LTE0
- Elsewhere: RCSB PDB 3AVU · PDBe 3AVU · UniProt P0A6P3 · UniProt P0A6N3 · UniProt Q8LTE0
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