MolNFT v1 · #57890 · protein
Crystal structure of the measles virus hemagglutinin bound to its cellular receptor slam (form I)
3ALZ: “Crystal structure of the measles virus hemagglutinin bound to its cellular receptor slam (form I)”. X-ray diffraction, 1 ligand (NAG), 10 pockets (best druggability 0.79). MolNFT v1 #57890 on GenesisL1: 3D structure, binding sites…
- PDB
- 3ALZ
- Type
- protein
- Length
- 526 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin; CDW150
- UniProt
- E2RZS2, Q9GJT3
- Ligands
- NAG
- Pockets
- 10 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemagglutinin | protein | 417 | 6% helix, 47% strand | E2RZS2 |
| B | CDW150 | protein | 109 | 3% helix, 47% strand | Q9GJT3 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 428 | 0.79 | 0.87 | 50 | empty |
| 2 | 190 | 0.61 | 0.83 | 30 | empty |
| 3 | 300 | 0.57 | 0.77 | 39 | empty |
| 4 | 71 | 0.46 | 0.82 | 21 | empty |
| 5 | 117 | 0.46 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1053 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 3ALZ · Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2RZS2
- Every structure of UniProt Q9GJT3
- Elsewhere: RCSB PDB 3ALZ · PDBe 3ALZ · UniProt E2RZS2 · UniProt Q9GJT3
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