Research workbench
Crystal structure of the measles virus hemagglutinin bound to its cellular receptor slam (form I)
Analyse Crystal structure of the measles virus hemagglutinin bound to its cellular… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ALZ
- Type
- protein
- Length
- 526 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin; CDW150
- UniProt
- E2RZS2, Q9GJT3
- Ligands
- NAG
- Pockets
- 10 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemagglutinin | protein | 417 | 6% helix, 47% strand | E2RZS2 |
| B | CDW150 | protein | 109 | 3% helix, 47% strand | Q9GJT3 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 428 | 0.79 | 0.87 | 50 | empty |
| 2 | 190 | 0.61 | 0.83 | 30 | empty |
| 3 | 300 | 0.57 | 0.77 | 39 | empty |
| 4 | 71 | 0.46 | 0.82 | 21 | empty |
| 5 | 117 | 0.46 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1053 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 3ALZ · Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2RZS2
- Every structure of UniProt Q9GJT3
- Elsewhere: RCSB PDB 3ALZ · PDBe 3ALZ · UniProt E2RZS2 · UniProt Q9GJT3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.