MolNFT v1 · #57523 · protein
Crystal structure of actin capping protein
3AA7 · F-actin-capping protein subunit alpha-1: “Crystal structure of actin capping protein”. X-ray diffraction, 1 ligand (BA), 5 pockets (best druggability 0.62). MolNFT v1 #57523 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3AA7
- Type
- protein
- Length
- 512 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315
- Ligands
- BA
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 269 | 41% helix, 33% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 243 | 39% helix, 36% strand | P14315 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 302 | 0.62 | 0.79 | 52 | empty |
| 2 | 111 | 0.39 | 0.76 | 18 | empty |
| 3 | 51 | 0.33 | 0.78 | 12 | empty |
| 4 | 68 | 0.29 | 0.73 | 19 | empty |
| 5 | 61 | 0.28 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 3673 Ų buried · 59 hydrogen bonds · protein-protein
Compared structures
- 3AA7 · Crystal structure of Actin capping protein · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Elsewhere: RCSB PDB 3AA7 · PDBe 3AA7 · UniProt P13127 · UniProt P14315
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