MolNFT v1 · #57494 · protein

Structure of pim-1 kinase crystallized in the presence of P27KIP1 carboxy-terminal peptide

3A99 · Proto-oncogene SERINE/THREONINE-protein kinase pim-1: “Structure of pim-1 kinase crystallized in the presence of P27KIP1 carboxy-terminal peptide”. X-ray diffraction, 2 ligands (ANP, MG), 1 pocket (best druggability 0.66). MolNFT v1…

PDB: 3A99
Type: protein
Length: 273 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene SERINE/THREONINE-protein kinase pim-1
EC: 2.7.11.1
UniProt: P11309
Ligands: ANP, MG
Pockets: 1 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proto-oncogene SERINE/THREONINE-protein kinase pim-1 (EC 2.7.11.1)	protein	273	39% helix, 22% strand	P11309

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	527	0.66	0.77	45	MG, ANP

Compared structures

3A99 · Structure of PIM-1 kinase crystallized in the presence of P27KIP1 Carboxy-terminal peptide · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11309
Elsewhere: RCSB PDB 3A99 · PDBe 3A99 · UniProt P11309

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