MolNFT v1 · #57476 · protein
Crystal structure of the TIAM2 phccex domain
3A8P · T-lymphoma invasion and metastasis-inducing protein 2: “Crystal structure of the TIAM2 phccex domain”. X-ray diffraction, 13 pockets (best druggability 0.79). MolNFT v1 #57476 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3A8P
- Type
- protein
- Length
- 920 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-lymphoma invasion and metastasis-inducing protein 2
- UniProt
- Q6ZPF3
- Pockets
- 13 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-lymphoma invasion and metastasis-inducing protein 2 | protein | 232 | 50% helix, 22% strand | Q6ZPF3 |
| B | T-lymphoma invasion and metastasis-inducing protein 2 | protein | 231 | 48% helix, 22% strand | Q6ZPF3 |
| C | T-lymphoma invasion and metastasis-inducing protein 2 | protein | 229 | 48% helix, 22% strand | Q6ZPF3 |
| D | T-lymphoma invasion and metastasis-inducing protein 2 | protein | 228 | 50% helix, 22% strand | Q6ZPF3 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1074 | 0.79 | 0.81 | 71 | empty |
| 2 | 473 | 0.69 | 0.79 | 47 | empty |
| 3 | 491 | 0.68 | 0.78 | 47 | empty |
| 4 | 455 | 0.66 | 0.78 | 47 | empty |
| 5 | 538 | 0.65 | 0.76 | 59 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1071 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1001 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 638 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6ZPF3
- Elsewhere: RCSB PDB 3A8P · PDBe 3A8P · UniProt Q6ZPF3
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