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Crystal structure of the TIAM2 phccex domain

Analyse Crystal structure of the TIAM2 phccex domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3A8P
Type: protein
Length: 920 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-lymphoma invasion and metastasis-inducing protein 2
UniProt: Q6ZPF3
Pockets: 13 · best druggability 0.79

Structure

x-ray diffraction · 4 distinct chains · 49% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	T-lymphoma invasion and metastasis-inducing protein 2	protein	232	50% helix, 22% strand	Q6ZPF3
B	T-lymphoma invasion and metastasis-inducing protein 2	protein	231	48% helix, 22% strand	Q6ZPF3
C	T-lymphoma invasion and metastasis-inducing protein 2	protein	229	48% helix, 22% strand	Q6ZPF3
D	T-lymphoma invasion and metastasis-inducing protein 2	protein	228	50% helix, 22% strand	Q6ZPF3

Pockets

13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1074	0.79	0.81	71	empty
2	473	0.69	0.79	47	empty
3	491	0.68	0.78	47	empty
4	455	0.66	0.78	47	empty
5	538	0.65	0.76	59	empty

Interfaces

3 interfaces between chains.

A–B · 1071 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 1001 Å² buried · 15 hydrogen bonds · protein-protein
A–C · 638 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3A8P · Crystal structure of the Tiam2 PHCCEx domain · the same entry in another collection · chain D against D, TM-score 1.00
Q6ZPF3 · AlphaFold monomer V2.0 prediction for T-lymphoma invasion and metastasis-inducing protein… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6ZPF3
Elsewhere: RCSB PDB 3A8P · PDBe 3A8P · UniProt Q6ZPF3

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