MolNFT v1 · #57388 · protein

Crystal structure of phosphorylated P70S6K1

3A62 · Ribosomal protein S6 kinase beta-1: “Crystal structure of phosphorylated P70S6K1”. X-ray diffraction, 2 ligands (STU, MN), 2 pockets (best druggability 0.69). MolNFT v1 #57388 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3A62
Type: protein
Length: 264 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosomal protein S6 kinase beta-1
EC: 2.7.11.1
UniProt: P23443
Ligands: STU, MN
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)	protein	264	36% helix, 17% strand	P23443

Ligands and binding sites

STU · Staurosporine · ligand · chains A
MN · Manganese (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	414	0.69	0.81	45	STU
2	60	0.32	0.76	14	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

3A62 · Crystal structure of phosphorylated p70S6K1 · the same entry in another collection · chain A against A, TM-score 1.00
P23443 · AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase beta-1 (P23443) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23443
Elsewhere: RCSB PDB 3A62 · PDBe 3A62 · UniProt P23443

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