UniProt P23443
Ribosomal protein S6 kinase beta-1 (P23443)
Ribosomal protein S6 kinase beta-1 (UniProt P23443), EC 2.7.11.1: 27 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P23443
- Protein
- Ribosomal protein S6 kinase beta-1
- EC
- 2.7.11.1
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 2 · 0 records with a druggable one
Structures
28 records of P23443 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3A60 | Crystal structure of unphosphorylated p70S6K1 (Form I) | x-ray diffraction | A, B | — | — |
| 3A60 | Crystal structure of unphosphorylated P70S6K1 (form I) | x-ray diffraction | A, B | — | — |
| 3A61 | Crystal structure of unphosphorylated p70S6K1 (Form II) | x-ray diffraction | A | — | — |
| 3A61 | Crystal structure of unphosphorylated P70S6K1 (form II) | x-ray diffraction | A | — | — |
| 3A62 | Crystal structure of phosphorylated p70S6K1 | x-ray diffraction | A | — | — |
| 3A62 | Crystal structure of phosphorylated P70S6K1 | x-ray diffraction | A | — | — |
| 3WE4 | Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative PF-4708671… | x-ray diffraction | A | — | — |
| 3WE4 | Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative pf-4708671… | x-ray diffraction | A | — | — |
| 3WF5 | Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative… | x-ray diffraction | A | — | — |
| 3WF5 | Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative… | x-ray diffraction | A | — | — |
| 3WF6 | Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative… | x-ray diffraction | A | — | — |
| 3WF6 | Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative… | x-ray diffraction | A | — | — |
| 3WF7 | Crystal structure of S6K1 kinase domain in complex with a purine derivative… | x-ray diffraction | A | — | — |
| 3WF7 | Crystal structure of S6K1 kinase domain in complex with a purine derivative… | x-ray diffraction | A | — | — |
| 3WF8 | Crystal structure of S6K1 kinase domain in complex with a quinoline derivative… | x-ray diffraction | A | — | — |
| 3WF8 | Crystal structure of S6K1 kinase domain in complex with a quinoline derivative… | x-ray diffraction | A | — | — |
| 3WF9 | Crystal structure of S6K1 kinase domain in complex with a quinoline derivative… | x-ray diffraction | A | — | — |
| 3WF9 | Crystal structure of S6K1 kinase domain in complex with a quinoline derivative… | x-ray diffraction | A | — | — |
| 4RLO | Human p70s6k1 with ruthenium-based inhibitor EM5 | x-ray diffraction | A, B | — | — |
| 4RLO | Human P70S6K1 with ruthenium-based inhibitor EM5 | x-ray diffraction | A, B | — | — |
| 4RLP | Human p70s6k1 with ruthenium-based inhibitor FL772 | x-ray diffraction | A | — | — |
| 4RLP | Human P70S6K1 with ruthenium-based inhibitor FL772 | x-ray diffraction | A | — | — |
| 5WBH | Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1 | x-ray diffraction | W | — | 2 (best 0.44) |
| 5WBH | Structure of the frb domain of mtor bound to a substrate recruitment peptide of S6K1 | x-ray diffraction | W | — | — |
| 5WBK | Crystal structure of the arabidopsis thaliana raptor in complex with the tos peptide of human S6K1 | x-ray diffraction | T | — | — |
| 7N91 | P70 S6K1 in complex with MSC2317067A-1 | x-ray diffraction | A, B | 1RJ | — |
| 7N93 | P70 S6K1 in complex with MSC2363318A-1 | x-ray diffraction | A, B | 1SK | — |
| P23443 | AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase beta-1 (P23443) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7N93 chain B against the predicted model P23443: TM-score 0.98, RMSD 1.05 Å
- 7N91 chain A against the predicted model P23443: TM-score 0.98, RMSD 1.03 Å
- 7N91 chain B against the predicted model P23443: TM-score 0.98, RMSD 1.14 Å
- 3A61 chain A against the predicted model P23443: TM-score 0.97, RMSD 1.10 Å
- 3A61 chain A against the predicted model P23443: TM-score 0.97, RMSD 1.10 Å
- 7N93 chain A against the predicted model P23443: TM-score 0.97, RMSD 1.21 Å
- 3A62 chain A against the predicted model P23443: TM-score 0.96, RMSD 1.41 Å
- 3A62 chain A against the predicted model P23443: TM-score 0.96, RMSD 1.41 Å
- 3WE4 chain A against the predicted model P23443: TM-score 0.94, RMSD 1.50 Å
- 3WE4 chain A against the predicted model P23443: TM-score 0.94, RMSD 1.50 Å
Elsewhere
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