MolNFT v1 · #56994 · protein

Rhamnose-binding lectin CSL3

2ZX3: “Rhamnose-binding lectin CSL3”. X-ray diffraction, 3 ligands (BGC, GLA, PO4), 4 pockets (best druggability 0.61). MolNFT v1 #56994 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZX3
Type: protein
Length: 390 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CSL3
Ligands: BGC, GLA, PO4
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CSL3	protein	195	16% helix, 36% strand	—

Ligands and binding sites

BGC · beta-D-glucopyranose · sugar · 4 copies · chains A, B
GLA · alpha-D-galactopyranose · sugar · 4 copies · chains A, B
PO4 · Phosphate ion · ion · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	272	0.61	0.79	40	PO4
2	223	0.59	0.80	43	empty
3	147	0.43	0.76	31	empty
4	120	0.42	0.76	28	empty

Interfaces

1 interface between chains.

A–B · 1550 Å² buried · 31 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

2ZX3 · Rhamnose-binding lectin CSL3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2ZX3 · PDBe 2ZX3

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