MolNFT v1 · #56877 · protein
Crystal structure of the parasporin-2 bacillus thuringiensis toxin that recognizes cancer cells
2ZTB · Crystal protein: “Crystal structure of the parasporin-2 bacillus thuringiensis toxin that recognizes cancer cells”. X-ray diffraction, 2 ligands (LU, CL), 2 pockets (best druggability 0.68). MolNFT v1 #56877 on GenesisL1: 3D…
- PDB
- 2ZTB
- Type
- protein
- Length
- 495 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Crystal protein
- UniProt
- Q7WZI1
- Ligands
- LU, CL
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 64% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Crystal protein | protein | 247 | 11% helix, 62% strand | Q7WZI1 |
| B | Crystal protein | protein | 248 | 11% helix, 65% strand | Q7WZI1 |
Ligands and binding sites
- LU · Lutetium (III) ion · metal · 3 copies · chains A, B
- CL · Chloride ion · ion · chains B
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 296 | 0.68 | 0.83 | 40 | empty |
| 2 | 190 | 0.59 | 0.81 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 795 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 2ZTB · Crystal structure of the parasporin-2 Bacillus thuringiensis toxin that recognizes cancer… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7WZI1
- Elsewhere: RCSB PDB 2ZTB · PDBe 2ZTB · UniProt Q7WZI1
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