MolNFT v1 · #56556 · protein

Crystal structure of the MUS81-EME1 complex

2ZIV · MUS81 protein: “Crystal structure of the MUS81-EME1 complex”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #56556 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZIV
Type: protein
Length: 550 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MUS81 protein; Crossover junction endonuclease EME1
EC: 3.1.22.-
UniProt: Q6GML8, Q96AY2
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MUS81 protein	protein	281	43% helix, 19% strand	Q6GML8
B	Crossover junction endonuclease EME1 (EC 3.1.22.-)	protein	269	40% helix, 13% strand	Q96AY2

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	427	0.74	0.83	38	empty
2	437	0.64	0.77	55	empty
3	347	0.62	0.78	45	empty
4	102	0.38	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 3711 Å² buried · 58 hydrogen bonds · protein-protein

Compared structures

2ZIV · Crystal structure of the Mus81-Eme1 complex · the same entry in another collection · chain A against A, TM-score 1.00
Q96AY2 · AlphaFold monomer V2.0 prediction for crossover junction endonuclease EME1 (Q96AY2) · a predicted model of the same protein · chain B against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6GML8
Every structure of UniProt Q96AY2
Elsewhere: RCSB PDB 2ZIV · PDBe 2ZIV · UniProt Q6GML8 · UniProt Q96AY2

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