Crystal structure of human galectin-9 N-terminal crd in complex with N-acetyllactosamine dimer (crystal 1)

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 54% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
• GAL · beta-D-galactopyranose · sugar · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 237 Ų buried · 2 hydrogen bonds · protein-protein

Compared structures

• 2ZHK · Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine… · the same entry in another collection · chain A against A, TM-score 1.00
• O00182 · AlphaFold monomer V2.0 prediction for galectin-9 (O00182) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O00182
• Elsewhere: RCSB PDB 2ZHK · PDBe 2ZHK · UniProt O00182