MolNFT v1 · #56271 · protein

Crystal structure of the apo-form of orotidine-5'- monophosphate decarboxylase from P.FALCIPARUM

2ZA2 · Orotidine 5'-phosphate decarboxylase: “Crystal structure of the apo-form of orotidine-5'- monophosphate decarboxylase from P.FALCIPARUM”. X-ray diffraction, 9 pockets (best druggability 0.70). MolNFT v1 #56271 on GenesisL1: 3D…

PDB: 2ZA2
Type: protein
Length: 616 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Orotidine 5'-phosphate decarboxylase
EC: 4.1.1.23
UniProt: Q8T6J6
Pockets: 9 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	protein	306	48% helix, 15% strand	Q8T6J6
B	Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	protein	310	43% helix, 16% strand	Q8T6J6

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	417	0.70	0.82	68	empty
2	316	0.64	0.80	48	empty
3	87	0.37	0.76	17	empty
4	94	0.37	0.75	18	empty
5	75	0.36	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 2249 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

2ZA2 · Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8T6J6
Elsewhere: RCSB PDB 2ZA2 · PDBe 2ZA2 · UniProt Q8T6J6

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