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Crystal structure of the apo-form of orotidine-5'- monophosphate decarboxylase from P.FALCIPARUM
Analyse Crystal structure of the apo-form of orotidine-5'- monophosphate decarboxylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZA2
- Type
- protein
- Length
- 616 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orotidine 5'-phosphate decarboxylase
- EC
- 4.1.1.23
- UniProt
- Q8T6J6
- Pockets
- 9 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) | protein | 306 | 48% helix, 15% strand | Q8T6J6 |
| B | Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) | protein | 310 | 43% helix, 16% strand | Q8T6J6 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 417 | 0.70 | 0.82 | 68 | empty |
| 2 | 316 | 0.64 | 0.80 | 48 | empty |
| 3 | 87 | 0.37 | 0.76 | 17 | empty |
| 4 | 94 | 0.37 | 0.75 | 18 | empty |
| 5 | 75 | 0.36 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2249 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 2ZA2 · Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8T6J6
- Elsewhere: RCSB PDB 2ZA2 · PDBe 2ZA2 · UniProt Q8T6J6
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