MolNFT v1 · #56135 · protein
Molecular basis for the inhibition of P53 by mdmx
2Z5S · MDM4 protein: “Molecular basis for the inhibition of P53 by mdmx”. X-ray diffraction, 1 pocket (best druggability 0.70). MolNFT v1 #56135 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2Z5S
- Type
- protein
- Length
- 296 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MDM4 protein; Cellular tumor antigen P53
- UniProt
- Q4V944, P04637
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 5 distinct chains · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | MDM4 protein | protein | 92 | 43% helix, 15% strand | Q4V944 |
| P, Q | Cellular tumor antigen P53 | protein | 11 | 45% helix, 0% strand | P04637 |
| N | MDM4 protein | protein | 86 | 45% helix, 19% strand | Q4V944 |
| O | MDM4 protein | protein | 86 | 47% helix, 19% strand | Q4V944 |
| R | Cellular tumor antigen P53 | protein | 10 | 50% helix, 0% strand | P04637 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 877 | 0.70 | 0.75 | 86 | empty |
Interfaces
9 interfaces between chains.
- O–R · 500 Ų buried · 4 hydrogen bonds · protein-protein
- N–O · 471 Ų buried · 7 hydrogen bonds · protein-protein
- M–P · 464 Ų buried · 3 hydrogen bonds · protein-protein
- N–Q · 438 Ų buried · 2 hydrogen bonds · protein-protein
- M–N · 315 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2Z5S · Molecular basis for the inhibition of p53 by Mdmx · the same entry in another collection · chain M against M, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4V944
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 2Z5S · PDBe 2Z5S · UniProt Q4V944 · UniProt P04637
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