MolNFT v1 · #56131 · protein
Complex of transportin 1 with jktbp nls
2Z5O · Transportin-1: “Complex of transportin 1 with jktbp nls”. X-ray diffraction, 5 pockets (best druggability 0.54). MolNFT v1 #56131 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2Z5O
- Type
- protein
- Length
- 844 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; Heterogeneous nuclear ribonucleoprotein D-like
- UniProt
- Q92973
- Pockets
- 5 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 834 | 76% helix, 0% strand | Q92973 |
| B | Heterogeneous nuclear ribonucleoprotein D-like | protein | 10 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.54 | 0.81 | 29 | empty |
| 2 | 88 | 0.39 | 0.77 | 21 | empty |
| 3 | 122 | 0.38 | 0.74 | 22 | empty |
| 4 | 78 | 0.37 | 0.76 | 13 | empty |
| 5 | 80 | 0.30 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 402 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Elsewhere: RCSB PDB 2Z5O · PDBe 2Z5O · UniProt Q92973
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