MolNFT v1 · #56130 · protein
Complex of transportin 1 with hnrnp D nls
2Z5N · Transportin-1: “Complex of transportin 1 with hnrnp D nls”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #56130 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2Z5N
- Type
- protein
- Length
- 855 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; Heterogeneous nuclear ribonucleoprotein D0
- UniProt
- Q92973, Q14103
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 840 | 70% helix, 0% strand | Q92973 |
| B | Heterogeneous nuclear ribonucleoprotein D0 | protein | 15 | 0% helix, 0% strand | Q14103 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 552 | 0.67 | 0.77 | 59 | empty |
| 2 | 243 | 0.57 | 0.78 | 28 | empty |
| 3 | 103 | 0.37 | 0.75 | 20 | empty |
| 4 | 115 | 0.37 | 0.74 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1133 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2Z5N · Complex of Transportin 1 with hnRNP D NLS · the same entry in another collection · chain A against A, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q14103 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein D0 (Q14103) · a predicted model of the same protein · chain B against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt Q14103
- Elsewhere: RCSB PDB 2Z5N · PDBe 2Z5N · UniProt Q92973 · UniProt Q14103
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