MolNFT v1 · #56126 · protein

Free transportin 1

2Z5J · Transportin-1: “Free transportin 1”. X-ray diffraction, 6 pockets (best druggability 0.52). MolNFT v1 #56126 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Z5J
Type: protein
Length: 835 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transportin-1
UniProt: Q92973
Pockets: 6 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transportin-1	protein	835	71% helix, 0% strand	Q92973

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	246	0.52	0.76	25	empty
2	95	0.48	0.80	16	empty
3	90	0.39	0.77	23	empty
4	64	0.39	0.79	11	empty
5	116	0.34	0.72	27	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2Z5J · Free Transportin 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92973
Elsewhere: RCSB PDB 2Z5J · PDBe 2Z5J · UniProt Q92973

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