MolNFT v1 · #55743 · protein

Solution structure of the PDZ-domain of human protease htra 1 precursor

2YTW · Serine protease HTRA1: “Solution structure of the PDZ-domain of human protease htra 1 precursor”. Solution nmr, 1 pocket (best druggability 0.37). MolNFT v1 #55743 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2YTW
Type: protein
Length: 118 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine protease HTRA1
EC: 3.4.21.-
UniProt: Q92743
Pockets: 1 · best druggability 0.37

Structure

solution nmr · 1 distinct chain · 17% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serine protease HTRA1 (EC 3.4.21.-)	protein	118	17% helix, 31% strand	Q92743

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.37	0.74	14	empty

Compared structures

2YTW · Solution structure of the PDZ-domain of human protease HTRA 1 precursor · the same entry in another collection · chain A against A, TM-score 1.00
Q92743 · AlphaFold monomer V2.0 prediction for serine protease HTRA1 (Q92743) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92743
Elsewhere: RCSB PDB 2YTW · PDBe 2YTW · UniProt Q92743

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