UniProt Q92743
Serine protease HTRA1 (Q92743)
Serine protease HTRA1 (UniProt Q92743), EC 3.4.21.-: 28 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q92743
- Protein
- Serine protease HTRA1
- EC
- 3.4.21.-
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 79 · 9 records with a druggable one
Structures
29 records of Q92743 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JOA | HtrA1 bound to an optimized peptide: NMR assignment of PDZ domain and ligand resonances | solution nmr | A | — | — |
| 2JOA | HTRA1 bound to an optimized peptide: NMR assignment of PDZ domain and ligand resonances | solution nmr | A | — | — |
| 2YTW | Solution structure of the PDZ-domain of human protease HTRA 1 precursor | solution nmr | A | — | — |
| 2YTW | Solution structure of the PDZ-domain of human protease htra 1 precursor | solution nmr | A | — | — |
| 3NUM | Substrate induced remodeling of the active site regulates HtrA1 activity | x-ray diffraction | A | — | — |
| 3NUM | Substrate induced remodeling of the active site regulates HTRA1 activity | x-ray diffraction | A | — | — |
| 3NWU | Substrate induced remodeling of the active site regulates HtrA1 activity | x-ray diffraction | A, B, C | — | — |
| 3NWU | Substrate induced remodeling of the active site regulates HTRA1 activity | x-ray diffraction | A, B, C | — | — |
| 3NZI | Substrate induced remodeling of the active site regulates HtrA1 activity | x-ray diffraction | A | — | — |
| 3NZI | Substrate induced remodeling of the active site regulates HTRA1 activity | x-ray diffraction | A | — | — |
| 3TJN | HtrA1 catalytic domain, apo form | x-ray diffraction | A, B, D | — | — |
| 3TJN | HTRA1 catalytic domain, apo form | x-ray diffraction | A, B, D | — | — |
| 3TJO | HtrA1 catalytic domain, mutationally inactivated | x-ray diffraction | A, B, D | — | — |
| 3TJO | HTRA1 catalytic domain, mutationally inactivated | x-ray diffraction | A, B, D | — | — |
| 3TJQ | N-domain of HtrA1 | x-ray diffraction | A | — | — |
| 3TJQ | N-domain of HTRA1 | x-ray diffraction | A | — | — |
| 6Z0E | HtrA1 inactive protease domain S328A with CARASIL mutation R274Q | x-ray diffraction | A, B | — | 1 (best 0.71) |
| 6Z0E | HTRA1 inactive protease domain S328A with carasil mutation R274Q | x-ray diffraction | A, B | — | — |
| 6Z0X | HtrA1 inactive protease domain S328A with CARASIL mutations D174R R274Q | x-ray diffraction | A, B, C | SO4 | 5 (best 0.56) |
| 6Z0X | HTRA1 inactive protease domain S328A with carasil mutations D174R R274Q | x-ray diffraction | A, B, C | SO4 | — |
| 6Z0Y | HtrA1 inactive protease domain S328A with CARASIL mutations D174R R274Q | x-ray diffraction | A, B, C | SO4 | 4 (best 0.67) |
| 6Z0Y | HTRA1 inactive protease domain S328A with carasil mutations D174R R274Q | x-ray diffraction | A, B, C | SO4 | — |
| 7SJN | HtrA1:Fab15H6.v4 complex | electron microscopy | A, B, C | — | 5 (best 0.75) |
| 7SJO | HtrA1S328A:Fab15H6.v4 complex | electron microscopy | A, B, C | — | 7 (best 0.73) |
| 8SDM | HTRA-1 PDSA bound to CKP 3B3 | x-ray diffraction | A, B, C | — | 6 (best 0.78) |
| 8SDP | HTRA-1 PDSA bound to CKP 3A7 | x-ray diffraction | A, B, C | SO4 | 11 (best 0.73) |
| 8SE7 | HTRA-1 PDSA bound to CKP 1A8 | x-ray diffraction | A, B, C, D, E, F, K, L, M, Q, R, S | — | 20 (best 0.75) |
| 8SE8 | HTRA-1 PD/SA bound to CKP 1G10 | x-ray diffraction | A, B, C, D, E, F, K, L, M, Q, R, S | SO4 | 20 (best 0.79) |
| Q92743 | AlphaFold monomer V2.0 prediction for serine protease HTRA1 (Q92743) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 6 records
Experiment against prediction
- 3NWU chain C against the predicted model Q92743: TM-score 0.98, RMSD 0.80 Å
- 3NWU chain C against the predicted model Q92743: TM-score 0.98, RMSD 0.80 Å
- 6Z0E chain B against the predicted model Q92743: TM-score 0.98, RMSD 0.87 Å
- 6Z0E chain B against the predicted model Q92743: TM-score 0.98, RMSD 0.87 Å
- 3NWU chain B against the predicted model Q92743: TM-score 0.98, RMSD 0.87 Å
- 3NWU chain B against the predicted model Q92743: TM-score 0.98, RMSD 0.87 Å
- 3NWU chain A against the predicted model Q92743: TM-score 0.98, RMSD 0.89 Å
- 3NWU chain A against the predicted model Q92743: TM-score 0.98, RMSD 0.89 Å
- 3TJN chain A against the predicted model Q92743: TM-score 0.97, RMSD 0.90 Å
- 3TJN chain A against the predicted model Q92743: TM-score 0.97, RMSD 0.90 Å
Elsewhere
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