MolNFT v1 · #55418 · protein

Structure of C1156Y mutant anaplastic lymphoma kinase

2YJS · ALK tyrosine kinase receptor: “Structure of C1156Y mutant anaplastic lymphoma kinase”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #55418 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2YJS
Type: protein
Length: 286 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ALK tyrosine kinase receptor
EC: 2.7.10.1
UniProt: Q9UM73
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ALK tyrosine kinase receptor (EC 2.7.10.1)	protein	286	43% helix, 15% strand	Q9UM73

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	219	0.49	0.75	30	empty

Compared structures

2YJS · Structure of C1156Y Mutant Anaplastic Lymphoma Kinase · the same entry in another collection · chain A against A, TM-score 1.00
Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UM73
Elsewhere: RCSB PDB 2YJS · PDBe 2YJS · UniProt Q9UM73

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