MolNFT v1 · #55102 · protein
Chromatin remodeling factor ISW1A(DEL_ATPASE)
2Y9Y · Imitation switch protein 1 (DEL_ATPASE): “Chromatin remodeling factor ISW1A(DEL_ATPASE)”. X-ray diffraction, 13 pockets (best druggability 0.75). MolNFT v1 #55102 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2Y9Y
- Type
- protein
- Length
- 869 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Imitation switch protein 1 (DEL_ATPASE); Iswi one complex protein 3
- UniProt
- P38144, P43596
- Pockets
- 13 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Imitation switch protein 1 (DEL_ATPASE) | protein | 277 | 55% helix, 0% strand | P38144 |
| B | Iswi one complex protein 3 | protein | 592 | 42% helix, 5% strand | P43596 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.75 | 0.98 | 20 | empty |
| 2 | 253 | 0.70 | 0.85 | 35 | empty |
| 3 | 453 | 0.64 | 0.77 | 41 | empty |
| 4 | 401 | 0.62 | 0.77 | 53 | empty |
| 5 | 75 | 0.61 | 0.90 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 2840 Ų buried · 46 hydrogen bonds · protein-protein
Compared structures
- 2Y9Y · Chromatin Remodeling Factor ISW1a(del_ATPase) · the same entry in another collection · chain A against A, TM-score 1.00
- P43596 · AlphaFold monomer V2.0 prediction for iswi one complex protein 3 (P43596) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P38144 · AlphaFold monomer V2.0 prediction for iswi chromatin-remodeling complex ATPase ISW1… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38144
- Every structure of UniProt P43596
- Elsewhere: RCSB PDB 2Y9Y · PDBe 2Y9Y · UniProt P38144 · UniProt P43596
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