MolNFT v1 · #55081 · protein

Crystal structure of mal adaptor protein

2Y92 · TOLL/INTERLEUKIN-1 receptor domain-containing adapter…: “Crystal structure of mal adaptor protein”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #55081 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Y92
Type: protein
Length: 127 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TOLL/INTERLEUKIN-1 receptor domain-containing adapter protein,
UniProt: P58753
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TOLL/INTERLEUKIN-1 receptor domain-containing adapter protein,	protein	127	45% helix, 19% strand	P58753

Ligands and binding sites

DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.31	0.74	16	empty

Modifications

Observed in the structure: 2 covalent, 2 disulfide (additive adduct, disulfide).

Compared structures

2Y92 · Crystal structure of MAL adaptor protein · the same entry in another collection · chain A against A, TM-score 1.00
P58753 · AlphaFold monomer V2.0 prediction for TOLL/INTERLEUKIN-1 receptor domain-containing… · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P58753
Elsewhere: RCSB PDB 2Y92 · PDBe 2Y92 · UniProt P58753

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