MolNFT v1 · #5489 · protein

Mouse importin alpha-SV40 large T antigen nls peptide complex

1EJL: “Mouse importin alpha-SV40 large T antigen nls peptide complex”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #5489 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1EJL
Type: protein
Length: 440 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SV40 large T antigen nls peptide; Importin alpha
UniProt: P03070, P52293
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	SV40 large T antigen nls peptide	protein	7	0% helix, 0% strand	P03070
I	Importin alpha	protein	426	73% helix, 0% strand	P52293

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.47	0.81	13	empty
2	54	0.26	0.74	11	empty

Interfaces

2 interfaces between chains.

B–I · 691 Å² buried · 17 hydrogen bonds · protein-protein
A–I · 621 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1EJL · Mouse importin alpha-SV40 large T antigen nls peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain I against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03070
Every structure of UniProt P52293
Elsewhere: RCSB PDB 1EJL · PDBe 1EJL · UniProt P03070 · UniProt P52293

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