MolNFT v1 · #5470 · protein
Cocrystal structure of the messenger RNA 5' cap-binding protein (EIF4E) bound to 7-methyl-GDP
1EJ1 · Eukaryotic translation initiation factor 4E: “Cocrystal structure of the messenger RNA 5' cap-binding protein (EIF4E) bound to 7-methyl-GDP”. X-ray diffraction, 1 ligand (M7G), 4 pockets (best druggability 0.68). MolNFT v1 #5470 on…
- PDB
- 1EJ1
- Type
- protein
- Length
- 368 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E
- UniProt
- P63073
- Ligands
- M7G
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 178 | 37% helix, 30% strand | P63073 |
| B | Eukaryotic translation initiation factor 4E | protein | 190 | 33% helix, 27% strand | P63073 |
Ligands and binding sites
- M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 418 | 0.68 | 0.80 | 36 | empty |
| 2 | 243 | 0.63 | 0.81 | 39 | empty |
| 3 | 107 | 0.44 | 0.78 | 20 | M7G |
| 4 | 120 | 0.44 | 0.77 | 21 | M7G |
Interfaces
1 interface between chains.
- A–B · 958 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1EJ1 · Cocrystal structure of the messenger RNA 5' cap-binding protein (EIF4E) bound to… · the same entry in another collection · chain A against A, TM-score 1.00
- P63073 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P63073) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63073
- Elsewhere: RCSB PDB 1EJ1 · PDBe 1EJ1 · UniProt P63073
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.