MolNFT v1 · #54687 · protein

Crystal structure of the DNA-binding domain of human P53 with extended N terminus

2XWR · Cellular tumor antigen P53: “Crystal structure of the DNA-binding domain of human P53 with extended N terminus”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.43). MolNFT v1 #54687 on GenesisL1: 3D structure…

PDB: 2XWR
Type: protein
Length: 399 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cellular tumor antigen P53
UniProt: P04637
Ligands: ZN
Pockets: 4 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cellular tumor antigen P53	protein	199	9% helix, 33% strand	P04637
B	Cellular tumor antigen P53	protein	200	10% helix, 33% strand	P04637

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.43	0.80	19	empty
2	101	0.40	0.76	21	empty
3	115	0.39	0.75	20	empty
4	105	0.38	0.75	22	empty

Interfaces

1 interface between chains.

A–B · 267 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2XWR · Crystal structure of the DNA-binding domain of human p53 with extended N terminus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04637
Elsewhere: RCSB PDB 2XWR · PDBe 2XWR · UniProt P04637

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.