MolNFT v1 · #54624 · protein
The G157C mutation in the escherichia COLI sliding clamp specifically affects initiation of replication
2XUR · DNA polymerase III subunit beta: “The G157C mutation in the escherichia COLI sliding clamp specifically affects initiation of replication”. X-ray diffraction, 5 pockets (best druggability 0.32). MolNFT v1 #54624 on GenesisL1: 3D…
- PDB
- 2XUR
- Type
- protein
- Length
- 730 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase III subunit beta
- EC
- 2.7.7.7
- UniProt
- P0A988
- Pockets
- 5 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA polymerase III subunit beta (EC 2.7.7.7) | protein | 366 | 22% helix, 46% strand | P0A988 |
| B | DNA polymerase III subunit beta (EC 2.7.7.7) | protein | 364 | 23% helix, 45% strand | P0A988 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.32 | 0.75 | 14 | empty |
| 2 | 71 | 0.31 | 0.74 | 22 | empty |
| 3 | 62 | 0.29 | 0.74 | 20 | empty |
| 4 | 57 | 0.29 | 0.75 | 15 | empty |
| 5 | 57 | 0.27 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1368 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 2XUR · The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A988 · AlphaFold monomer V2.0 prediction for beta sliding clamp (P0A988) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A988
- Elsewhere: RCSB PDB 2XUR · PDBe 2XUR · UniProt P0A988
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.