MolNFT v1 · #54426 · protein
Crystal structure of the N-terminal three domains of the skeletal muscle ryanodine receptor (RYR1)
2XOA · Ryanodine receptor 1: “Crystal structure of the N-terminal three domains of the skeletal muscle ryanodine receptor (RYR1)”. X-ray diffraction, 5 pockets (best druggability 0.70). MolNFT v1 #54426 on GenesisL1: 3D structure, binding…
- PDB
- 2XOA
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ryanodine receptor 1
- UniProt
- P11716
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 24% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ryanodine receptor 1 | protein | 461 | 24% helix, 31% strand | P11716 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 425 | 0.70 | 0.82 | 53 | empty |
| 2 | 75 | 0.53 | 0.85 | 18 | empty |
| 3 | 230 | 0.51 | 0.76 | 36 | empty |
| 4 | 115 | 0.48 | 0.80 | 22 | empty |
| 5 | 88 | 0.30 | 0.72 | 22 | empty |
Compared structures
- 2XOA · Crystal Structure of the N-terminal three domains of the skeletal muscle Ryanodine… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11716
- Elsewhere: RCSB PDB 2XOA · PDBe 2XOA · UniProt P11716
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