MolNFT v1 · #53924 · protein
Tet repressor (class D) in complex with iso-7-chlortetracycline
2X9D · Tetracycline repressor protein class D: “Tet repressor (class D) in complex with iso-7-chlortetracycline”. X-ray diffraction, 2 ligands (ITC, CL), 2 pockets (best druggability 0.63). MolNFT v1 #53924 on GenesisL1: 3D structure…
- PDB
- 2X9D
- Type
- protein
- Length
- 195 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tetracycline repressor protein class D
- UniProt
- P0ACT4
- Ligands
- ITC, CL
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tetracycline repressor protein class D | protein | 195 | 71% helix, 0% strand | P0ACT4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 293 | 0.63 | 0.80 | 32 | ITC |
| 2 | 63 | 0.28 | 0.74 | 16 | empty |
Compared structures
- 2X9D · Tet repressor (class D) in complex with iso-7-chlortetracycline · the same entry in another collection · chain A against A, TM-score 1.00
- P0ACT4 · AlphaFold monomer V2.0 prediction for tetracycline repressor protein class D (P0ACT4) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACT4
- Elsewhere: RCSB PDB 2X9D · PDBe 2X9D · UniProt P0ACT4
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