MolNFT v1 · #5369 · protein
Three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution
1EFV: “Three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution”. X-ray diffraction, 2 ligands (FAD, AMP), 6 pockets (best druggability 0.83). MolNFT v1 #5369 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1EFV
- Type
- protein
- Length
- 564 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Electron transfer flavoprotein
- UniProt
- P13804, P38117
- Ligands
- FAD, AMP
- Pockets
- 6 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Electron transfer flavoprotein | protein | 312 | 32% helix, 30% strand | P13804 |
| B | Electron transfer flavoprotein | protein | 252 | 31% helix, 31% strand | P38117 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A, B
- AMP · Adenosine monophosphate · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 633 | 0.83 | 0.87 | 59 | AMP |
| 2 | 799 | 0.77 | 0.81 | 79 | empty |
| 3 | 56 | 0.65 | 0.95 | 19 | empty |
| 4 | 266 | 0.58 | 0.78 | 39 | empty |
| 5 | 246 | 0.58 | 0.79 | 38 | FAD |
Interfaces
1 interface between chains.
- A–B · 3502 Ų buried · 57 hydrogen bonds · protein-protein
Compared structures
- 1EFV · Three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution · the same entry in another collection · chain A against A, TM-score 1.00
- P13804 · AlphaFold monomer V2.0 prediction for electron transfer flavoprotein subunit alpha… · a predicted model of the same protein · chain A against A, TM-score 1.00
- P38117 · AlphaFold monomer V2.0 prediction for electron transfer flavoprotein subunit beta (P38117) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13804
- Every structure of UniProt P38117
- Elsewhere: RCSB PDB 1EFV · PDBe 1EFV · UniProt P13804 · UniProt P38117
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