MolNFT v1 · #53541 · protein
Clostridium perfringens alpha-toxin strain NCTC8237
2WXT · Phospholipase C: “Clostridium perfringens alpha-toxin strain NCTC8237”. X-ray diffraction, 3 ligands (CD, CA, ZN), 4 pockets (best druggability 0.69). MolNFT v1 #53541 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2WXT
- Type
- protein
- Length
- 359 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase C
- EC
- 3.1.4.3
- UniProt
- Q0TV31
- Ligands
- CD, CA, ZN
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phospholipase C (EC 3.1.4.3) | protein | 359 | 45% helix, 17% strand | Q0TV31 |
Ligands and binding sites
- CD · Cadmium ion · metal · 8 copies · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.69 | 0.89 | 31 | empty |
| 2 | 132 | 0.50 | 0.80 | 25 | empty |
| 3 | 80 | 0.41 | 0.79 | 14 | empty |
| 4 | 105 | 0.39 | 0.75 | 16 | CD |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0TV31
- Elsewhere: RCSB PDB 2WXT · PDBe 2WXT · UniProt Q0TV31
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