MolNFT v1 · #53073 · protein

Crystal structure of the LG1-3 region of the laminin ALPHA2 chain

2WJS · Laminin subunit alpha-2: “Crystal structure of the LG1-3 region of the laminin ALPHA2 chain”. X-ray diffraction, 2 ligands (NAG, CA), 3 pockets (best druggability 0.61). MolNFT v1 #53073 on GenesisL1: 3D structure, binding sites and…

PDB: 2WJS
Type: protein
Length: 519 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Laminin subunit alpha-2
UniProt: Q60675
Ligands: NAG, CA
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 1% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Laminin subunit alpha-2	protein	519	1% helix, 48% strand	Q60675

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
CA · Calcium ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.61	0.90	23	empty
2	57	0.33	0.77	13	empty
3	55	0.26	0.73	18	empty

Modifications

Observed in the structure: 4 disulfide, 4 glycan (disulfide, N-glycosylation).

Compared structures

2WJS · Crystal structure of the LG1-3 region of the laminin alpha2 chain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q60675
Elsewhere: RCSB PDB 2WJS · PDBe 2WJS · UniProt Q60675

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.