MolNFT v1 · #52940 · protein

Crystal structure of the N-terminal signalling domain of human dhh with calcium

2WFR · Desert hedgehog protein N-product: “Crystal structure of the N-terminal signalling domain of human dhh with calcium”. X-ray diffraction, 3 ligands (CA, ZN, SO4), 1 pocket (best druggability 0.24). MolNFT v1 #52940 on GenesisL1: 3D…

PDB: 2WFR
Type: protein
Length: 165 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Desert hedgehog protein N-product
UniProt: O43323
Ligands: CA, ZN, SO4
Pockets: 1 · best druggability 0.24

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Desert hedgehog protein N-product	protein	165	29% helix, 19% strand	O43323

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A
ZN · Zinc ion · metal · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.24	0.73	15	ZN

Compared structures

2WFR · Crystal structure of the N-terminal signalling domain of human Dhh with calcium · the same entry in another collection · chain A against A, TM-score 1.00
O43323 · AlphaFold monomer V2.0 prediction for desert hedgehog protein (O43323) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43323
Elsewhere: RCSB PDB 2WFR · PDBe 2WFR · UniProt O43323

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