MolNFT v1 · #52767 · protein

Crystal structure of mycobacterium tuberculosis unknown function protein RV2714

2WAM · Conserved hypothetical alanine and leucine rich protein: “Crystal structure of mycobacterium tuberculosis unknown function protein RV2714”. X-ray diffraction, 12 pockets (best druggability 0.71). MolNFT v1 #52767 on GenesisL1: 3D…

PDB: 2WAM
Type: protein
Length: 856 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Conserved hypothetical alanine and leucine rich protein
UniProt: O07213
Pockets: 12 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 39% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Conserved hypothetical alanine and leucine rich protein	protein	294	40% helix, 26% strand	O07213
B	Conserved hypothetical alanine and leucine rich protein	protein	287	39% helix, 25% strand	O07213
C	Conserved hypothetical alanine and leucine rich protein	protein	275	38% helix, 27% strand	O07213

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.71	0.97	27	empty
2	297	0.67	0.82	52	empty
3	259	0.62	0.81	42	empty
4	244	0.60	0.79	33	empty
5	224	0.48	0.74	31	empty

Interfaces

3 interfaces between chains.

B–C · 1362 Å² buried · 33 hydrogen bonds · protein-protein
A–C · 1343 Å² buried · 27 hydrogen bonds · protein-protein
A–B · 1340 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

2WAM · Crystal structure of Mycobacterium tuberculosis unknown function protein Rv2714 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O07213
Elsewhere: RCSB PDB 2WAM · PDBe 2WAM · UniProt O07213

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