Research workbench
Crystal structure of mycobacterium tuberculosis unknown function protein RV2714
Analyse Crystal structure of mycobacterium tuberculosis unknown function protein RV2714 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WAM
- Type
- protein
- Length
- 856 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved hypothetical alanine and leucine rich protein
- UniProt
- O07213
- Pockets
- 12 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Conserved hypothetical alanine and leucine rich protein | protein | 294 | 40% helix, 26% strand | O07213 |
| B | Conserved hypothetical alanine and leucine rich protein | protein | 287 | 39% helix, 25% strand | O07213 |
| C | Conserved hypothetical alanine and leucine rich protein | protein | 275 | 38% helix, 27% strand | O07213 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.71 | 0.97 | 27 | empty |
| 2 | 297 | 0.67 | 0.82 | 52 | empty |
| 3 | 259 | 0.62 | 0.81 | 42 | empty |
| 4 | 244 | 0.60 | 0.79 | 33 | empty |
| 5 | 224 | 0.48 | 0.74 | 31 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1362 Ų buried · 33 hydrogen bonds · protein-protein
- A–C · 1343 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 1340 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 2WAM · Crystal structure of Mycobacterium tuberculosis unknown function protein Rv2714 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O07213
- Elsewhere: RCSB PDB 2WAM · PDBe 2WAM · UniProt O07213
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