MolNFT v1 · #52754 · protein
Structure of the M202V mutant of human filamin B actin binding domain at 1.85 ångström resolution
2WA7 · Filamin-B: “Structure of the M202V mutant of human filamin B actin binding domain at 1.85 ångström resolution”. X-ray diffraction, 1 ligand (CO3), 1 pocket (best druggability 0.42). MolNFT v1 #52754 on GenesisL1: 3D structure…
- PDB
- 2WA7
- Type
- protein
- Length
- 225 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Filamin-B
- UniProt
- O75369
- Ligands
- CO3
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Filamin-B | protein | 225 | 58% helix, 0% strand | O75369 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.42 | 0.78 | 21 | empty |
Compared structures
- 2WA7 · Structure of the M202V mutant of human filamin b actin binding domain at 1.85 Angstrom… · the same entry in another collection · chain A against A, TM-score 1.00
- O75369 · AlphaFold monomer V2.0 prediction for filamin-B (O75369) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75369
- Elsewhere: RCSB PDB 2WA7 · PDBe 2WA7 · UniProt O75369
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