MolNFT v1 · #5203 · protein
The RUNX1 runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate DNA binding
1EAO · Runt-related transcription factor 1: “The RUNX1 runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate…”. X-ray diffraction, 1 ligand (BR), 1 pocket (best druggability 0.34). MolNFT v1…
- PDB
- 1EAO
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Runt-related transcription factor 1
- UniProt
- Q03347
- Ligands
- BR
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Runt-related transcription factor 1 | protein | 124 | 6% helix, 41% strand | Q03347 |
Ligands and binding sites
- BR · Bromide ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.34 | 0.76 | 18 | BR |
Interfaces
1 interface between chains.
- A–B · 257 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1EAO · THE RUNX1 Runt domain at 1.4A resolution: a structural switch and specifically bound… · the same entry in another collection · chain B against B, TM-score 1.00
- Q03347 · AlphaFold monomer V2.0 prediction for runt-related transcription factor 1 (Q03347) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03347
- Elsewhere: RCSB PDB 1EAO · PDBe 1EAO · UniProt Q03347
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