MolNFT v1 · #51903 · protein

Structural analysis of the sulfolobus solfataricus mcm protein N-terminal domain

2VL6 · Minichromosome maintenance protein mcm: “Structural analysis of the sulfolobus solfataricus mcm protein N-terminal domain”. X-ray diffraction, 1 ligand (ZN), 10 pockets (best druggability 0.82). MolNFT v1 #51903 on GenesisL1: 3D…

PDB: 2VL6
Type: protein
Length: 777 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Minichromosome maintenance protein mcm
UniProt: Q9UXG1
Ligands: ZN
Pockets: 10 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Minichromosome maintenance protein mcm	protein	259	26% helix, 32% strand	Q9UXG1

Ligands and binding sites

ZN · Zinc ion · metal · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1120	0.82	0.83	119	empty
2	464	0.66	0.78	46	empty
3	171	0.57	0.81	23	empty
4	142	0.55	0.81	22	empty
5	108	0.54	0.83	18	empty

Interfaces

3 interfaces between chains.

A–C · 1497 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 1472 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 45 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2VL6 · Structural analysis of the sulfolobus solfataricus mcm protein N- terminal domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9UXG1 · AlphaFold monomer V2.0 prediction for minichromosome maintenance protein mcm (Q9UXG1) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UXG1
Elsewhere: RCSB PDB 2VL6 · PDBe 2VL6 · UniProt Q9UXG1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.