MolNFT v1 · #5179 · protein
Alpha subunit of a. brasilense glutamate synthase
1EA0 · Glutamate synthase [NADPH] large chain: “Alpha subunit of a. brasilense glutamate synthase”. X-ray diffraction, 4 ligands (OMT, FMN, AKG), 20 pockets (best druggability 0.85). MolNFT v1 #5179 on GenesisL1: 3D structure, binding…
- PDB
- 1EA0
- Type
- protein
- Length
- 2,904 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate synthase [NADPH] large chain
- EC
- 1.4.1.13
- UniProt
- Q05755
- Ligands
- OMT, FMN, AKG, F3S
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutamate synthase [NADPH] large chain (EC 1.4.1.13) | protein | 1452 | 37% helix, 18% strand | Q05755 |
Ligands and binding sites
- OMT · S-dioxymethionine · ligand · 2 copies · chains A, B
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
- AKG · 2-oxoglutaric acid · ligand · 2 copies · chains A, B
- F3S · FE3-S4 cluster · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 426 | 0.85 | 0.92 | 75 | FMN, AKG |
| 2 | 456 | 0.83 | 0.91 | 80 | FMN, AKG |
| 3 | 967 | 0.82 | 0.83 | 106 | OMT |
| 4 | 539 | 0.79 | 0.86 | 72 | OMT |
| 5 | 707 | 0.75 | 0.80 | 62 | empty |
Interfaces
1 interface between chains.
- A–B · 2154 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05755
- Elsewhere: RCSB PDB 1EA0 · PDBe 1EA0 · UniProt Q05755
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