MolNFT v1 · #51766 · protein

Structure of a loop C-sheet serpin polymer

2VH4 · Tengpin: “Structure of a loop C-sheet serpin polymer”. X-ray diffraction, 8 pockets (best druggability 0.70). MolNFT v1 #51766 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2VH4
Type: protein
Length: 754 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tengpin
UniProt: Q8R9P5
Pockets: 8 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tengpin	protein	380	29% helix, 37% strand	Q8R9P5
B	Tengpin	protein	374	28% helix, 36% strand	Q8R9P5

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	759	0.70	0.76	62	empty
2	150	0.48	0.77	20	empty
3	67	0.48	0.83	22	empty
4	129	0.39	0.74	24	empty
5	53	0.33	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 261 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2VH4 · Structure of a loop C-sheet serpin polymer · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8R9P5
Elsewhere: RCSB PDB 2VH4 · PDBe 2VH4 · UniProt Q8R9P5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.