MolNFT v1 · #51752 · protein

Crystal structure of human ips-1 card

2VGQ · Sugar ABC transporter substrate-binding protein…: “Crystal structure of human ips-1 card”. X-ray diffraction, 2 ligands (GLC, SO4), 4 pockets (best druggability 0.70). MolNFT v1 #51752 on GenesisL1: 3D structure, binding sites and…

PDB: 2VGQ
Type: protein
Length: 461 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sugar ABC transporter substrate-binding protein, mitochondrial antiviral-signaling protein
UniProt: A0A0B1N7A9, Q7Z434
Ligands: GLC, SO4
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sugar ABC transporter substrate-binding protein, mitochondrial antiviral-signaling protein	protein	461	53% helix, 16% strand	A0A0B1N7A9, Q7Z434

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A
SO4 · Sulfate ion · ion · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	363	0.70	0.82	33	GLC
2	319	0.55	0.75	46	empty
3	55	0.38	0.80	16	empty
4	83	0.31	0.73	21	empty

Compared structures

2VGQ · Crystal Structure of Human IPS-1 CARD · the same entry in another collection · chain A against A, TM-score 1.00
Q7Z434 · AlphaFold monomer V2.0 prediction for mitochondrial antiviral- signaling protein (Q7Z434) · a predicted model of the same protein · chain A against A, TM-score 0.20

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0B1N7A9
Every structure of UniProt Q7Z434
Elsewhere: RCSB PDB 2VGQ · PDBe 2VGQ · UniProt A0A0B1N7A9 · UniProt Q7Z434

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