MolNFT v1 · #51680 · protein
Insights into kinetochore-DNA interactions from the structure of CEP3P
2VEQ · Centromere DNA-binding protein complex CBF3 subunit B: “Insights into kinetochore-DNA interactions from the structure of CEP3P”. X-ray diffraction, 9 pockets (best druggability 0.81). MolNFT v1 #51680 on GenesisL1: 3D structure…
- PDB
- 2VEQ
- Type
- protein
- Length
- 520 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere DNA-binding protein complex CBF3 subunit B
- UniProt
- P40969
- Pockets
- 9 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Centromere DNA-binding protein complex CBF3 subunit B | protein | 520 | 71% helix, 1% strand | P40969 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 452 | 0.81 | 0.89 | 58 | BME |
| 2 | 124 | 0.44 | 0.76 | 22 | empty |
| 3 | 113 | 0.43 | 0.77 | 23 | empty |
| 4 | 92 | 0.43 | 0.79 | 14 | empty |
| 5 | 122 | 0.41 | 0.75 | 14 | empty |
Modifications
Observed in the structure: 1 covalent, 1 disulfide (additive adduct, disulfide).
Compared structures
- 2VEQ · Insights into kinetochore-DNA interactions from the structure of Cep3p · the same entry in another collection · chain A against A, TM-score 1.00
- P40969 · AlphaFold monomer V2.0 prediction for centromere DNA-binding protein complex CBF3 subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40969
- Elsewhere: RCSB PDB 2VEQ · PDBe 2VEQ · UniProt P40969
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