MolNFT v1 · #51664 · protein

Xray structure of ftsk gamma domain (P. aeruginosa)

2VE8 · DNA translocase ftsk: “Xray structure of ftsk gamma domain (P. aeruginosa)”. X-ray diffraction, 4 pockets (best druggability 0.87). MolNFT v1 #51664 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2VE8
Type: protein
Length: 515 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA translocase ftsk
UniProt: Q9I0M3
Pockets: 4 · best druggability 0.87

Structure

x-ray diffraction · 8 distinct chains · 50% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA translocase ftsk	protein	67	48% helix, 3% strand	Q9I0M3
B	DNA translocase ftsk	protein	65	49% helix, 3% strand	Q9I0M3
C	DNA translocase ftsk	protein	62	52% helix, 3% strand	Q9I0M3
D	DNA translocase ftsk	protein	68	47% helix, 3% strand	Q9I0M3
E	DNA translocase ftsk	protein	66	48% helix, 3% strand	Q9I0M3
F	DNA translocase ftsk	protein	65	49% helix, 3% strand	Q9I0M3
G	DNA translocase ftsk	protein	60	53% helix, 3% strand	Q9I0M3
H	DNA translocase ftsk	protein	62	52% helix, 3% strand	Q9I0M3

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1028	0.87	0.88	121	empty
2	116	0.76	0.96	33	empty
3	58	0.41	0.81	18	empty
4	61	0.35	0.78	15	empty

Interfaces

20 interfaces between chains.

A–D · 455 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 438 Å² buried · 6 hydrogen bonds · protein-protein
B–E · 435 Å² buried · 10 hydrogen bonds · protein-protein
D–F · 418 Å² buried · 9 hydrogen bonds · protein-protein
A–G · 400 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

2VE8 · Xray structure of FtsK gamma domain (P. aeruginosa) · the same entry in another collection · chain H against H, TM-score 1.00
Q9I0M3 · AlphaFold monomer V2.0 prediction for DNA translocase ftsk (Q9I0M3) · a predicted model of the same protein · chain F against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I0M3
Elsewhere: RCSB PDB 2VE8 · PDBe 2VE8 · UniProt Q9I0M3

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