MolNFT v1 · #51521 · protein
Human aminoimidazole ribonucleotide synthetase
2V9Y · Phosphoribosylformylglycinamidine cyclo-ligase: “Human aminoimidazole ribonucleotide synthetase”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.60). MolNFT v1 #51521 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2V9Y
- Type
- protein
- Length
- 621 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosylformylglycinamidine cyclo-ligase
- EC
- 6.3.3.1
- UniProt
- P22102
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) | protein | 314 | 37% helix, 25% strand | P22102 |
| B | Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) | protein | 307 | 36% helix, 25% strand | P22102 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 398 | 0.60 | 0.76 | 47 | empty |
| 2 | 65 | 0.30 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 241 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22102
- Elsewhere: RCSB PDB 2V9Y · PDBe 2V9Y · UniProt P22102
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