MolNFT v1 · #51050 · protein
Crystal structure of human ribonucleotide reductase subunit R2
2UW2 · Ribonucleoside-diphosphate reductase M2 subunit: “Crystal structure of human ribonucleotide reductase subunit R2”. X-ray diffraction, 1 ligand (FE), 3 pockets (best druggability 0.55). MolNFT v1 #51050 on GenesisL1: 3D structure…
- PDB
- 2UW2
- Type
- protein
- Length
- 275 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonucleoside-diphosphate reductase M2 subunit
- EC
- 1.17.4.1
- UniProt
- P31350
- Ligands
- FE
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribonucleoside-diphosphate reductase M2 subunit (EC 1.17.4.1) | protein | 275 | 69% helix, 0% strand | P31350 |
Ligands and binding sites
- FE · Fe (III) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.55 | 0.88 | 17 | empty |
| 2 | 122 | 0.51 | 0.80 | 20 | empty |
| 3 | 53 | 0.28 | 0.74 | 14 | empty |
Compared structures
- 2UW2 · Crystal structure of human ribonucleotide reductase subunit R2 · the same entry in another collection · chain A against A, TM-score 1.00
- P31350 · AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase subunit M2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31350
- Elsewhere: RCSB PDB 2UW2 · PDBe 2UW2 · UniProt P31350
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